The WHO recommends that trivalent vaccines for use in the 2025-2026 Northern Hemisphere season contain the following:

Egg based vaccines:

an A/Victoria/4897/2022 (H1N1)pdm09-like virus;

an A/Croatia/10136RV/2023 (H3N2)-like virus; and

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus.

Cell or recombinant based vaccines:

an A/Wisconsin/67/2022 (H1N1)pdm09-like virus;

an A/District of Columbia/27/2023 (H3N2)-like virus; and

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus .

For quadrivalent egg- or cell culture-based or recombinant vaccines for use in the 2025-2026 northern hemisphere influenza season: While the B/Yamagata lineage vaccine component should be excluded as it is no longer warranted, where quadrivalent vaccines are still in use, the B/Yamagata lineage component remains unchanged:

Egg-, cell- or recombinant-based Vaccines

a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus.

Full WHO Recommendation

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The AIVC met in October 2024 and recommended that the following viruses be used for influenza vaccines in the 2025 Southern Hemisphere influenza season:

Egg based trivalent influenza vaccines:

an A/Victoria/4897/2022 (H1N1)pdm09-like virus;

an A/Croatia/10136RV/2023 (H3N2)-like virus; and

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus.

Cell-based trivalent influenza vaccines:

an an A/Wisconsin/67/2022 (H1N1)pdm09-like virus;

a an A//District of Columbia/27/2023 (H3N2)-like virus; and

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus.

The recommendation for the B/Yamagata lineage component of quadrivalent influenza vaccines remains unchanged from previous recommendations:

a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus.

See the TGA website for further information

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The WHO recommends that trivalent vaccines for use in the 2025 Southern Hemisphere season contain the following:

Egg-based vaccines:

an A/Victoria/4897/2022 (H1N1)pdm09-like virus

an A/Croatia/10136RV/2023 (H3N2)-like virus; and

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus.

Cell culture-, recombinant protein- or nucleic acid-based vaccines

an A/Wisconsin/67/2022 (H1N1)pdm09-like virus;

an A/District of Columbia/27/2023 (H3N2)-like virus; and

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus.

The recommendation for the B/Yamagata lineage component of quadrivalent influenza vaccines remains unchanged from previous recommendations

a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus

Full WHO Recommendation

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